Caps for Glass Ampoules

Aluminum-Plastic Caps for Pharmaceutical Glass Ampoules

Aluminum-plastic caps for glass ampoules are the crimped closure that seals an injectable ampoule after filling. Each cap combines a ductile aluminum shell — which deforms against the ampoule neck under the crimping tool to form a hermetic, tamper-evident seal — with an inner plastic or elastomer liner that contacts the product and provides the actual barrier. Together they protect injectable drugs, vaccines and biological products from moisture, oxygen and microbial ingress throughout the shelf life of the product.

Rimzer produces these caps in 13mm, 16mm, 20mm and 22mm neck finishes, in one-piece (open-top) and two-piece (tear-off flip-off) formats, with a choice of aluminum thickness and liner compound. The aluminum is lacquered on the exterior for corrosion resistance and coding; the interior liner is formulated for compatibility with the drug formulation and is available in non-toxic, latex-free, biocompatible grades that comply with USP, EP and CP requirements. Because the seal is formed by mechanical crimping rather than heat, no induction equipment is needed at the filling line.

Quick facts: MOQ 100,000 pcs  |  Lead time 5–7 working days for standard sizes  |  Free samples  |  Custom aluminum thickness, liner compound, colour and printing available

Specifications

Applications

Supplied to pharmaceutical manufacturers, contract filling organisations and injectable-drug producers in South America, Southeast Asia, the Middle East, Europe and Russia. Typical uses include:

• Injectables and infusions — small-volume parenterals, anaesthetics, antibiotics and vitamins in 1–20mL glass ampoules.
• Vaccines and biologicals — formulations that need a fully hermetic barrier and a tamper-evident closure.
• Electrolytes and saline — larger 10–20mL ampoules for clinical diluents and irrigation solutions.
• Veterinary injectables — the same crimped seal, in smaller batch quantities.

Key Advantages

• Hermetic crimped seal — the aluminium shell deforms into the ampoule neck groove, giving a gas-tight, tamper-evident closure that cannot be reopened without visible damage.
• Two-piece tear-off convenience — the flip-off/tear-off format lets clinical staff open the ampoule without a separate tool, reducing contamination risk at the point of use.
• Drug-contact-safe liner — non-toxic, latex-free and biocompatible compounds that resist interaction with sensitive formulations.
• Corrosion resistant — exterior lacquer protects the aluminium through transport and sterilisation cycles.
• No capital equipment needed — seals mechanically on any standard ampoule crimping tool, so no induction sealer is required.
• Full customisation — neck size, aluminium thickness, liner compound, colour and printing all specified to your filling line.

Why Choose Taizhou Rimzer

Taizhou Rimzer Rubber & Plastic Co., Ltd is a professional bottle packaging supplier with over 20 years of industry experience. Our 23,000 m² factory with 85 skilled employees delivers over one billion pieces per year to 100+ customers worldwide. We supply bottle factories, pharmaceutical and agrochemical plants, food & beverage producers, cosmetics factories and trading companies — from containers to seal liners and closures, one reliable source. Every ampoule cap order is backed by incoming material purity testing, dimensional accuracy checks and leakage / sterility validation before shipment.

Frequently Asked Questions

What is the difference between one-piece and two-piece ampoule caps?

A one-piece cap is a single aluminium shell with an open top — the ampoule is opened by snapping the glass neck. A two-piece cap adds a plastic flip-off or tear-off button on top of the aluminium shell, which the clinician removes first; this gives a cleaner, more controlled opening and a clearer tamper indication. Two-piece caps are the usual choice for vaccines and biologicals.

Do these caps require an induction sealing machine?

No. Ampoule caps seal by mechanical crimping: the aluminium is compressed into the neck groove of the glass ampoule with a crimping tool or inline crimper. No heat or induction equipment is involved.

Which neck finish sizes do you produce?

13mm, 16mm, 20mm and 22mm are standard. If your ampoule uses a non-standard neck, send the drawing or a sample — we tool custom sizes.

Are the caps suitable for terminal sterilisation?

Yes, provided the correct liner compound is selected for your sterilisation method (steam, dry heat or ethylene oxide). Tell us your sterilisation cycle and we will match the liner grade and confirm suitability in writing.

How do you control quality on pharmaceutical closures?

Three stages: incoming inspection of aluminium strip and liner compound (purity, thickness, hardness), in-process dimensional checks on shell diameter and height, and final leakage / sterility validation on retention samples from every batch.

Can you print batch number and expiry date?

Yes. Batch number, expiry date, logo and warning text can all be printed on the aluminium surface. Send your artwork and we will confirm the print area available on your chosen shell size.

What is the MOQ and lead time?

MOQ is 100,000 pcs. Standard sizes ship in 5–7 working days; custom batches take 12–18 days after artwork and sample approval.

Are samples free?

Yes, samples are free. Sample quantity and courier cost are negotiable depending on your location and project scope.

Can you supply the matching glass ampoules as well?

We can quote glass ampoules alongside the caps so the closure and container are matched from one source — see Pharmaceutical Glass Ampoules.